Disclaimer: Compounded medications have not been approved by the FDA and due to state and federal regulations, we are unable to compound any medications that are commercially available.

Over the last 6 months there has been an increase in interest and requests for a topical tofacitinib 2% (Brand name Xeljanz) compound to treat alopecia areata (AA) and Vitiligo. Studies and blogs are surfacing on the internet from the positive outcomes regarding this therapy option. Additionally, Dermatologists, Physician Assistants and Nurse Practitioners are being exposed to the outcomes of this treatment option at Dermatology Conferences across the nation.

Tofacitinib (Brand name Xeljanz) is a Janus kinase (JAK) inhibitor. According to the labeling, JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function.

Alternate delivery application as topical compound will help curtail the cost of the branded manufactured product. Insurance companies will not cover the cost of the oral medications for diagnoses outside of what the drug was intended for. Cost of these oral medications that have been approved for other disease states can costly if not covered by your insurance.

Lower costs options are available when choosing a compounded medication and have ranged from $150.00 to $350.00 for a 30gm (ml’s) of tofacitinib 2%. Compounding a medication for cost reasons only is not aloud due to state and federal regulations. However, compounds can be made when the dosage form or type is not commercially available. Compounded medications are not FDA approved, but are legally allowed upon the receipt of valid prescription that is written for a specific patient. Additionally, keep in mind that patients may still experience side effects for using a compounded medication and it is imperative to work along with an experienced compounding pharmacist to provide the safest outcomes possible.

Choosing an ACHC (PCAB) accredited pharmacy can offer an extra layer of professional trust. These pharmacies are independently inspected and follow requirements that meet and exceed a high level of performance and compliance for patient care.

"The rationale for using these treatments was based on the cytokine signaling pathways responsible for driving vitiligo"

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