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LDN / Auto Immune

Low Dose Naltrexone (LDN)

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect by an increased level of endorphins (naturally occurring opioids – specifically OGF). LDN has been demonstrated to reduce symptom severity and could help in conditions such as:

  • Fibromyalgia
  • Chronic Fatigue Syndrome
  • Crohn’s disease
  • Lyme Disease
  • Multiple sclerosis
  • Complex regional pain syndrome. 
  • Autoimmune conditions
  • Psoriasis

LDN also has shown benefit in a variety of autoimmune conditions.

Suggested Method of Therapy (The following information was taken from https://ldnresearchtrust.org/what-is-ldn.)

Your doctor will usually start treatment at an ultra-low dose and increase this gradually over a period of weeks – until you are stable and side effect free.

The starting dose can vary from 0.5mg to 1.5mg – and is usually increased over 4 - 8 weeks to 4.5mg or higher. Some doctors increase this to twice daily, for certain medical conditions.

For Autoimmune Diseases, patients typically start at 1mg and increase to 4.5mg daily over a period of 4 weeks.

However, for Hashimoto's Thyroiditis, Chronic Fatigue Syndrome or Fibromyalgia, the starting dose is usually 0.5mg and is increased by 0.5mg a week until a daily dose of 4.5mg is reached.

For Cancer, LDN can be taken at similar doses, but must be avoided the week before and the week after cancer chemotherapy. This does not include a drug called tamoxifen or daily medications for prostate cancer.